Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by control
Cell localization:
Nucleus. Cytoplasm. Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.
Isotype:
IgG1
Positive control:
293T cell lysates.
Storage conditions:
Store at +4? after thawing. Aliquot store at -20?. Avoid repeated freeze / thaw cycles.
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