Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus .Positively regulates MAPK signal transduction pathway.Dephosphorylates GAB1, ARHGAP35 and EGFR.Dep
Cell localization:
Cytoplasm, Nucleus.
Isotype:
IgG
Positive control:
Jurkat cell lysate, Hela cell lysate.
Storage conditions:
Store at +4? after thawing. Aliquot store at -20? or -80?. Avoid repeated freeze / thaw cycles.
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