Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays
Cell localization:
Cell junction. Cell membrane.
Isotype:
IgG
Positive control:
A431 cell lysate, HepG2 cell lysate, SK-Br-3 cell lysate, human breast cancer tissue, human kidney tissue, SK-Br-3.
Storage conditions:
Store at +4? after thawing. Aliquot store at -20?. Avoid repeated freeze / thaw cycles.
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