| Supplier: | Boster |
|---|---|
| Reference: | A00059 |
| Name: | Anti-SMAD3-S208 Antibody |
| Category: | Antibody |
| Subcategory: | Primary Antibodies |
| Research Area: | Cancer,Developmental Biology,Metabolism,Neuroscience,Signal Transduction |
| Aditional Names: | Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3 |
| Unit: | 80ul 400ul |
| Clonality: | Polyclonal |
| Price: | Consultar |
| Immunogen: | This SMAD3 antibody is generated from rabbits immuni |
| Host: | Rabbit |
| Reactivity: | Human, Mouse |
| Application: | WB,Flow Cytometry,IF,IHC-P |
| Description: | Boster Bio Anti-SMAD3-S208 Antibody (Catalog # A00059). Tested in WB, Flow Cytometry, IF, IHC-P application(s). This antibody reacts with Human, Mouse. |
| Function: | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes th |
| Cell localization: | Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969, PubMed:21145499). Through the action of the phosphatase PPM1A, released from the SMAD |
| Isotype: | Rabbit IgG |
| Purification: | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage conditions: | Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Assay inforation: | IF: 1:10-1:50 WB: 1:1000 IHC-P: 1:10-1:50 FC: 1:10-1:50 |