| Supplier: | Boster |
|---|---|
| Reference: | EK0337 |
| Name: | Human FASL / CD95LG / CD95 Ligand ELISA Kit PicoKine® |
| Category: | ELISA kit |
| Subcategory: | PicoKine® ELISA Kits |
| Research Area: | Apoptosis,Caspases,Cell Biology,Cytokines,Hematopoietic Progenitors,Immunology,Innate Immunity,Intracellular,Lymphoid,Receptors,Stem Cells,T Lymphocytic Lineage,TNF Superfamily |
| Aditional Names: | Tumor necrosis factor ligand superfamily member 6;Apoptosis antigen ligand;APTL;CD95 ligand;CD95-L;Fas antigen ligand;Fas ligand;FasL;CD178;Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form;Receptor-binding FasL ectodomain;Soluble Fas ligand;sFasL;ADAM10-processed FasL form;APL;FasL intracellular domain;FasL ICD;SPPL2A-processed FasL form;SPA;FASLG;APT1LG1, CD95L, FASL, TNFSF6; |
| Unit: | 96 wells/kit, with removable strips. |
| Price: | Consultar |
| Immunogen: | Expression system for standard: CHO; Immunogen seque |
| Reactivity: | Human |
| Cross Reactivity: | There is no detectable cross-reactivity with other relevant proteins. |
| Application: | ELISA |
| Description: | Human FASL / CD95LG / CD95 Ligand ELISA Kit PicoKine® (96 Tests). Quantitate Human FASLG in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 2pg/ml. |
| Function: | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:92 |
| Cell localization: | Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the |
| Storage conditions: | Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
| Assay inforation: | Dilution ratio of 1:1, concentration in serum and plasma is 40-218 pg/ml. |